Sinomenine is an alkaloid extracted from the dry cane of the deciduous tangled vines, Sinomenium chinense and Caulis Sinomenii. Sinomenine has analgesic, antitussive, local anesthesia, antihypertensive, anti-inflammatory, and can release histamine and inhibit smooth muscle activity. It is clinically used to treat various acute and chronic arthritis, rheumatism and rheumatoid arthritis, bone Arthritis, synovitis, frozen shoulder, senile low back pain, soft tissue injury, various neuropathic pain, etc.