Shiitake Mushroom have been using history for thousands of years in Japan and China. Which is also known as a food and medicinal fungus. For a long time, people have believed that mushrooms can grow their energy, treat colds and remove intestinal parasites. Mushrooms contain fat, carbohydrates, proteins, fibers, vitamins and minerals. However, the key component is called polysaccharides lentinan. Lentinan is extracted from mushroom crushed mycelium, which is rich in polysaccharides and lignin. The use of mushrooms in the mushroom top and stem growth before the emergence of mycelium, crushed after the manufacture of mushroom products may reduce the infectivity of hepatitis B. Mushrooms can also stimulate leukocytes to produce interferons. In the laboratory study it shows that it helps to enhance immunity.